王凯喆 博士,副研究员
王凯喆,2020年博士毕业于中国科学院上海应用物理研究所,后在上海交通大学从事博士后研究,合作导师樊春海院士。2022年加入中国科学院宁波材料所,任“春蕾人才”副研究员。
主要研究方向是基于细胞外囊泡和DNA纳米技术发展新型可编程纳米材料,用于药物递送、疾病诊疗。目前,以第一作者和通讯作者在Advanced Materials(×2)、Nano Letters、ACS Nano、Small、Journal of Neuroinflammation 等杂志发表多篇SCI论文,总影响因子127.4。研究获得国家自然科学基金青年基金、中国博士后基金面上项目、中国科学院宁波材料所“春蕾人才”基金、宁波甬江创新人才等基金资助。申请发明专利4项。担任中国抗癌协会纳米肿瘤学专业委员会青年委员。Extracellular Vesicle等杂志青年编委。
E-mail: wangkaizhe@nimte.ac.cn
► 研究方向:
1. 细胞外囊泡生物特征解析、工程化应用;
2. 可编程DNA纳米材料
► 代表性论文:
1. Yao X, He D, Wei P, Niu Z, Chen H, Li L, Fu P, Wang Y, Lou S, Qian S, Zheng J#, Zuo G#, Wang K#. DNA Nanomaterial-Empowered Surface Engineering of Extracellular Vesicles. Advanced Materials, 2023, e2306852.
2. Wang K*, Wei Y*, Xie X, Li Q, Liu X, Wang L, Li J, Wu J, Fan C. DNA-programmed stem cell niches via orthogonal extracellular vesicle-cell communications. Advanced Materials, 2023, 35(45), e2302323.
3. Wang K*, Zhou L*, Li J*, Liu W, Wei Y, Guo Z, Fan C, Hu J, Li B, Wang L. Label-free and three-dimensional visualization reveals the dynamic of plasma membrane-derived extracellular vesicles. Nano letters, 2020, 20(9):6313-6319.
4. Wang K, Wei Y, Liu W, Liu L, Guo Z, Fan C, ... & Li B. Mechanical stress-dependent autophagy components release via extracellular nanovesicles in tumor cells[J]. ACS nano, 2019,13(4):4589-4602
5. Wang K*, Ye L*, Lu H, Chen H, Zhang Y, Huang Y, & Zheng J. TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase[J]. Journal of neuroinflammation, 2017, 14(1):87.
6. Wei Y*, Wang K*(Co-first), Luo S, et al. Programmable DNA hydrogels as artificial extracellular matrix[J]. Small, 2022: 2107640.
7. Ma Y*, Wang K* (Co-first), Pan J, Fan Z, Tian C, Deng X, ... & Zheng J. Induced neural progenitor cells abundantly secrete extracellular vesicles and promote the proliferation of neural progenitors via extracellular signal–regulated kinase pathways[J]. Neurobiology of disease, 2019,124:322-334.
8. Liu W*, Guo Y*, Wang K* (Co-first), Zhou X, Wang Y, ... & Li B. Atomic force microscopy-based single-molecule force spectroscopy detects DNA base mismatches[J]. Nanoscale, 2019,11(37):17206-17210.
9. Zhang Y*, Wang K* (Co-first), Pan J, ... & Wang F. Exosome mediates epithelial mesenchymal transition cascade in retinal pigment epithelial cells, implication for proliferative vitreoretinopathy[J]. Journal of cellular and molecular medicine. 2020. DOI: 10.1111/jcmm.15951.